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hi this is dr. jay park oh it caused medical training today weamp;#39;re going to discuss Dysport in 1950 researchers at McGill discovered that botulinum toxin from the bacteria Clostridium botulinum presynaptic Li blocked the release of acetylcholine from motor nerve terminals the effect was muscle weakening due to chemical denervation it was also discovered that botulinum toxin blocked the exocytosis of acetylcholine by enzymatically degrading portions of d soluble and ethyl mal amide sensitive factor attachment protein receptor proteins also known as snare in the 1970s dr. Alan Scott an ophthalmologist was seeking an alternative to surgery for the correction of strabismus he published his first study using the formulated botulinum toxin called alkaline amp;#39;m into the extraocular muscles in 1980 in 1989 on a botulinum toxin a was fda-approved for Street business in 1992 dr. Jean Carruthers noticed an improvement in glabellar lines in patients treated with oculina and published