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antimicrobial resistance is a global challenge but some old antibiotics still work when used responsibly for more than 90 years penicillin has been keeping us safe from many life-threatening infections although it is one of our oldest antibiotics it is still widely unsuccessfully used to treat syphilis a sexually transmitted disease the bacteria which causes syphilis has never developed resistance to penicillin syphilis is especially dangerous in pregnancy as the infection can lead to miscarriage stillbirth prematurity low birth weight serious problems for the infected baby or neonatal death quality assured benzethine benzyl penicillin a long-acting variant of penicillin remains the safest and most effective antibiotic for pregnant mothers to use unlike other drugs penicillin treats the unborn baby too and the bacteria are completely killed off when exposed to the drug serious negative effects from penicillin are extremely rare pregnant women and their partners should get teste