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The first step in the central dogma is transcription, where DNA is converted into RNA. This occurs in the nucleus of eukaryotic cells. Transcription has three phases: initiation, elongation, and termination. In prokaryotes, transcription occurs in the cytoplasm. The process starts by transcribing RNA from a DNA template, and eventually produces a pre-mRNA that needs to be processed. The signal to end transcription is important to ensure accurate RNA production.