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In this video tutorial, Carla from Clinical Physio discusses key questions to ask during a subjective examination, focusing on past medical history, drug history, and social history. She introduces the acronym "hashtag thread Sox" to remember important areas to cover. Each letter represents a specific medical condition: hash for fractures, T for thyroid conditions, H for heart conditions, R for rheumatoid conditions, I for epilepsy, A for asthma and other breathing issues, D for diabetes, S for previous use of steroids, O for osteoporosis, C for personal or family history of cancer, and S for history of surgery. Carla emphasizes these points for effective patient assessment.