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How to form equation release

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A line passes through the points negative 3, 6 and 6, 0. Find the equation of this line in point slope form, slope intercept form, standard form. And the way to think about these, these are just three different ways of writing the same equation. So if you give me one of them, we can manipulate it to get any of the other ones. But just so you know what these are, point slope form, lets say the point x1, y1 are, lets say that that is a point on the line. And when someone puts this little subscript here, so if they just write an x, that means were talking about a variable that can take on any value. If someone writes x with a subscript 1 and a y with a subscript 1, thats like saying a particular value x and a particular value of y, or a particular coordinate. And youll see that when we do the example. But point slope form says that, look, if I know a particular point, and if I know the slope of the line, then putting that line in point slope form would be y minus y1 is equal to m ti

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What is the formula for release kinetics?

The fundamental principle for evaluation of the kinetics of drug release was offered by Noyes and Whitney in 1897 as the equation (10): dM/dt = KS (Cs с Ct) (1) where M, is the mass transferred with respect to time, t, by dissolution from the solid particle of instanta- neous surface, S, under the effect of the

What is the first order drug release equation?

First order model Equation (5) can be expressed as: log C = log C0 с Kt / 2.303 (6) where C0 is the initial concentration of drug, k is the first order rate constant, and t is the time (28).

How does controlled drug release work?

When glassy hydrophilic polymeric systems are placed in an aqueous solution including body fluids, water diffuses into the system. The water uptake results in the swelling of the polymeric particles followed by drug release (swelling-controlled release).

What is Higuchi equation drug release?

Considering the dissolution of a lipophilic, homogeneous, planar matrix, the relationship initially proposed by Higuchi is(5.15) f 1 = Q = D 2 C C s C s t where Q is the amount of drug released on time t by area unit, C is the initial amount of drug contained in dosage form, Cs is the solubility of active agent in

What is Higuchi equation used for?

Fifty years ago, the legendary Professor Takeru Higuchi published the derivation of an equation that allowed for the quantification of drug release from thin ointment films, containing finely dispersed drug into a perfect sink. This became the famous Higuchi equation whose fiftieth anniversary we celebrate this year.

What is Higuchi square root law?

Abstract. One of the conditions of derivation of the Higuchi square root law is that A/epsilon greater than S/2 where A is drug content per cubic centimeter of matrix tablet, epsilon is the porosity, and S is the solubility of the drug in the dissolution medium. In actuality, A/epsilon should be larger than S.

What is the drug release used for?

Drug release refers to the process in which drug solutes migrate from the initial position in the polymeric system to the polymers outer surface and then to the release medium [1].

What is the purpose of Higuchi model?

The Higuchi model for the rate of drug release from matrix devices where the drug loading exceeds the solubility in the matrix medium, whose 50-year anniversary is celebrated in this issue, has proven to be a robust framework and an invaluable tool in developing a docHub part of the modern controlled drug delivery

What is the importance of drug release?

Drug release is crucial for the efficacy of the treatment and for the best patient compliance. The major objective of the pharmacokinetic modulation is to perform the lowest number of the least invasive administration, preserving the therapeutic effect.

What does Higuchi equation describe?

English: The Higuchi equation describes the release of a substance (brown particles) uniformly suspended in an insoluble matrix (light brown) by diffusion (amount released as a function of time, t). The released amount is absorbed by the acceptor medium (light blue).

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