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how to add and subtract multiple cells in Excel one of the great things about Excel is the ease with which you can perform lengthy calculations in this example I have some items I have the opening stock purchases made some sales returns shortage so I need to add some of these numbers and I need to subtract some of them so it is very simple to do this in Excel I just select the cell where I want the result displayed start with an equal sign now I click on the opening stock filler where I get the cell reference then I want to add the purchases done then I want to subtract so minus the sales then I want to add the returns and then I want to again subtract the shortage so once this is done I press enter and here I get the final quantity available after adding and subtracting the various numbers I can then copy this down to the rest of the sets and I have the total quantities available for each item so this is how you add and subtract multiple cells in Excel please read the appended article