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Dr. Rishi Desai from Osmosis discusses three key tips for taking a thorough patient history. He emphasizes the importance of understanding the mechanics, which include the chief complaint, History of Present Illness (HPI), past medical history, medications, allergies, family history, social history, and review of systems. His first tip is to listen well and empathize with the patient. He points out that patients seek human interaction rather than just answers, as they could choose a robotic system for basic questions. The focus should be on building rapport and understanding the patient's concerns deeply to provide more personalized care.