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[Rhonda]: The question that I had for you is, like, Ive talked with Dr. Valter Longo, he was on the podcast, and he talked quite a bit about his research on prolonged fasting in both rodents and also in humans and how the prolonged fast, at least, in rodents is 48 hours, which in humans is around 4 days, 4 to 5 days. And that was able to very robustly, not only activate autophagy, but also cell death, and that was followed by a regeneration period. But, the question is do we know what the minimum amount of fasting time is for humans or rodents that can activate autophagy? So for example, when Im not pregnant, I usually followed a very time restricted eating schedule where I like to eat all of my food within at least 10 hours, and then I fast for 14 hours every night. Some people do even more strict. They eat within 8 hours and they fast for 16 hours. Does that 16-hour fast induce any autophagy in any of our tissues? Is there any evidence, do we know? [Dr. Kroemer]: We dont know. So
