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chronic liver disease are one of the leading cause of major health problems worldwide very often skin manifestations are the first sign of liver disease few skin lesions are typically seen in liver disease but some skin changes are General and can be seen in many other diseases so lets discuss the signs one by one Elish discoloration of skin is a typical finding of liver disease it is evident when the serum level of bilirubin exceeds 2.5 or 3 milligram per DL the color of the skin varies from yellow to Brown depending on the amount of bilirubin in your blood the white portion of the eyes also turns yellow this skin changes is due to excess accumulation of bilirubin under the skin next important skin manifestation is spider angioma you may see wave-like clusters of blood vessels under your skin which is called spider angioma or a spider till injector shear the lesion contains a central red spot and a reddish extension which radiate outward like a spiders web they may appears as multip