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As we age, the tiniest blood vessels in our bodies wither and die, reducing the blood flow to organs and tissues. Vascular aging causes many diseases -- cardiovascular, neurological, muscle wasting, frailty, and even aging. Here at Harvard Medical School, weve reversed the process in mice, setting the stage for radical new therapies to help people. The new study has unraveled the cascade of interactions between blood vessels and muscles. Endothelial cells, which line the walls of blood vessels, are essential for the health and growth of the vessels. And as endothelial cells age, blood vessels begin to atrophy and die. Blood flow to many parts of the body diminishes, organs and tissues begin to function less well. Blood vessel demise hits muscles especially hard, because muscles rely on a robust blood supply for their function. This process can be slowed down with regular exercise, but only up to a point. Over time, even exercise fails to stave off blood vessel demise and muscle loss.
