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Cardiac output is the amount of blood pumped by each ventricle in one minute. It is the product of stroke volume the amount of blood pumped in one heartbeat, and heart rate the number of beats in one minute. An increase in either stroke volume or heart rate results in increased cardiac output, and vice versa. For example, during physical exercises, the heart beats faster to put out more blood in response to higher demand of the body. It is noteworthy that the ventricles do not eject all the blood they contain in one beat. In a typical example, a ventricle is filled with about 100ml of blood at the end of its load, but only 60ml is ejected during contraction. This corresponds to an ejection fraction of 60%. The 100ml is the end-diastolic volume, or EDV. The 40ml that remains in the ventricle after contraction is the end-systolic volume, or ESV. The stroke volume equals EDV minus ESV, and is dependent on 3 factors: contractility, preload, and afterload. Contractility refers to the f
