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Welcome to 2 minute neuroscience, where I explain neuroscience topics in 2 minutes or less. In this installment I will discuss long-term potentiation, or LTP. LTP is a process by which synaptic connections between neurons become stronger with frequent activation. LTP is thought to be a way in which the brain changes in response to experience, and thus may be an mechanism underlying learning and memory. There are a number of ways in which LTP can occur. The best-known mechanism involves a glutamate receptor known as the NMDA receptor. In NMDA-receptor dependent LTP, glutamate release first activates a subtype of glutamate receptor known as the AMPA receptor. NMDA receptors are found nearby these AMPA receptors, but are not activated by low levels of glutamate release because the ion channel of an NMDA receptor is blocked by a magnesium ion. If frequent action potentials cause greater stimulation of AMPA receptors, however, this will cause the postsynaptic neuron to depolarize, which ev

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What are the stages of MND progression?

The different types of MND cause similar symptoms and have three stages: early, middle, and advanced. The diseases progress at different speeds and vary in severity.

What are the last stages of MND?

The final stages of MND will usually involve gradual weakening of the breathing muscles and increasing sleepiness. This is usually the cause of death, either because of an infection or because the muscles stop working. Specialist palliative care supports quality of life through symptom control.

How quickly does MND progress?

The symptoms of MND start gradually over weeks and months. They tend to appear on one side of the body first and get progressively worse.

What happens at the end of MND?

The final stages of MND will usually involve gradual weakening of the breathing muscles and increasing sleepiness. This is usually the cause of death, either because of an infection or because the muscles stop working. Specialist palliative care supports quality of life through symptom control.

What is the progress of MND?

Motor neurone disease gets gradually worse over time. Moving around, swallowing and breathing get increasingly difficult, and treatments like a feeding tube or breathing air through a face mask may be needed. The condition eventually leads to death, but how long it takes to docHub this stage varies a lot.

How quickly do people deteriorate with MND?

A third of people with MND die within a year of diagnosis, and more than half die within two years. Up to half of all people with MND will be affected by some degree of cognitive or behavioural change. This increases to 8 in 10 in the final stage of the disease.

What are the 3 stages of MND?

The different types of MND cause similar symptoms and have three stages: early, middle, and advanced. The diseases progress at different speeds and vary in severity.

How long do the final stages of MND last?

The most common form of MND, ALS, usually begins with limb weakness, although in approximately 20% of patients it has a bulbar onset (dysfunction of speech and swallowing). The mean period between diagnosis and death in MND is three years, with only 10% surviving longer than eight years.

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