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my name is laurence raber i'm an interventional cardiologist working at byrne university hospital in byrne switzerland the trial is asking the question whether vulnerable plaques that are responsible for myocardial infarction or sudden cardiac death in a large proportion whether we can [Music] ameliorate those plaques by high intensity lipid lowering with the use of alirocumab on top of high intensity statin therapy we enrolled a total of 300 patients presenting with either non-stemi or stemi they were treated in their culprit lesion with a stent and if they had non-obstructive disease in the two non-infarct-related vessels we imaged them using intra-corner imaging consisting of three techniques first they combine with a combined catheter using intravascular ultrasound and near infrared spectroscopy those two catheters can assess the black burden and the lipid pool both important vulnerability characteristics and the second catheter we used for intercontinental imaging is optical cohe...