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In America, the blood industry is a multibillion-dollar business with centers throughout the country. The North American blood market was valued at $3.3 billion in 2021. There is a high demand for human blood, as there is no substitute, leading to occasional shortages with potentially life-threatening consequences. Efforts are being made to address hurdles for groups like gay men who were previously banned from donating. Major players in blood collection include Grifols, CSL Plasma, Takeda's BioLife, and Octapharma, with donors being compensated, especially for plasma used in pharmaceutical therapies.