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hello and good morning my name is laurence raver from burn university hospital switzerland switzerland is located about 2000 kilometers southern to where david ling is coming from from sweden the topic of my talk is pharmacological treatment of vulnerable plaques vps background and little information on the ongoing pacman amy trial these are my disclosures the morphological architecture of plaques leading to coronary thrombosis and subsequent death is characterized in two-thirds of cases by a as you can see here lipid or necrotic core a large plaque burden that does not necessarily compromise the lumen so much and a thin overlying fibrous cap with macrophages on the top and as you can see here as i said in two-thirds of cases in this large meta-analysis summarizing more than 1800 autopsy at death this was found this black type was found to be the leading cause for thrombosis for coronary thrombosis now tools to study these plaques in vivo are available and you are already familiar wit