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Long-term potentiation (LTP) is a process that strengthens synaptic connections between neurons through frequent activation, serving as a mechanism for learning and memory. A key player in LTP is the NMDA receptor, which is activated following the initial activation of AMPA receptors by glutamate release. NMDA receptors have a magnesium ion blocking their ion channel and require strong stimulation to activate. When action potentials lead to increased activation of AMPA receptors, the postsynaptic neuron depolarizes, which allows NMDA receptors to respond. This process illustrates how the brain can adapt based on experiences.