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Hi everyone, this is Aaysha Cader for PCR Online and Iamp;#39;m delighted to have with me today Dr Giovanni Luigi De Maria from the Oxford Heart Center and we are coming to you live from TCT in San Francisco. Welcome Dr De Maria. Thank you for having me. Congratulations on your late-breaking presentation today. Dr De Maria has just presented the results of the PICSO-AMI study, which is the first multicentre randomised control trial that looked at the efficacy of this device in STEMI in conjunction with primary PCI. So, tell us a bit about what PICSO is and . the hypothesis and the design of your study. Sure, thanks I think one of the things to put in Perspective, because the rational for the study originally comes from the still need to find a way to reduce myocardial infarct size massive progress has been made in the treatment of STEMI. In our abilities over the yearsand the pressure controlled intermittent coronary sinus occlusion it is possible, I think, it can su