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In America, the blood industry is a multibillion-dollar market valued at $3.3 billion in 2021, with U.S. blood contributing over 2% to exports. Demand is high and maintaining supply is challenging, with reports of only a one-day supply available at times, leading to potential life-or-death situations. The blood resource, while vital for public health, faces issues such as a historic FDA ban affecting gay men’s ability to donate, which some argue does not adhere to scientific evidence. Major companies in blood collection, like Grifols and CSL Plasma, compensate donors, and the plasma collected is used for therapies developed by large pharmaceutical firms.