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mucociliary clearance is that first line of defense that the lung has to protect itself against bacteria or any other potentially harmful particle that we inhale every minute of every day people assist if fibrosis have a real problem with mucociliary clearance this is because that CF protein that is malfunctioning in people with cystic fibrosis is responsible for regulating the amount of salt and water that gets secreted into that airway surface now thatamp;#39;s important because you need an adequate amount of salt and water to make that mucus that secreted moveable so ultimately what happens when mucus gets stuck down in the lung we develop chronic infections and this leads to a really destruction of the Airways and in cystic fibrosis so there are several important clinical trials that are upcoming to address this problem of mucociliary clearance and cystic fibrosis these range from those that are focused first at the CFTR protein itself so we know that there are a number of