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Maternal serum screening is an optional blood test that can be done during pregnancy. There are many different versions of this testing. You may have heard it called the Quad Screen, Integrated Screen, Sequential Screen or First Trimester Screen. Maternal serum screening provides information about some specific conditions: Open neural tube defects including spina bifida and anencephaly Down syndrome, Trisomy 18, and in some cases Trisomy 13. These conditions are all very different from one another. It is not always possible to know before a child is born how much their health will be affected. In some cases, maternal serum screening results may suggest twins, or indicate a higher chance for abdominal wall defects, or other health concerns or genetic conditions in the baby. It is important to know that maternal serum screening cannot detect all genetic conditions or birth defects. No test can guarantee the birth of a healthy baby. This type of testing measures different prote