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In this video tutorial by Carla on clinical physio, she discusses essential questions to ask during a subjective examination, focusing on past medical history, drug history, and social history. She introduces the acronym "hashtag thread Sox," which helps remember key medical conditions. Each letter stands for specific health issues: Hash (fractures), T (thyroid conditions), H (heart conditions), R (rheumatoid conditions), I (epilepsy), A (asthma and breathing pathologies), D (diabetes), S (previous steroid use), O (osteoporosis), C (personal or family history of cancer), and S (history of surgery). Carla emphasizes the importance of these areas when assessing a patient.