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In America, blood is a multibillion-dollar industry, valued at $3.3 billion in 2021, comprising over 2% of U.S. exports. The demand for human blood is hard to meet, with current supplies at only one day. Shortages pose potential life-or-death consequences. Despite its vital importance as a public health resource, some groups face hurdles; notably, a historic FDA study may reverse the ban preventing gay men from donating blood. Major players in blood collection include Grifols, CSL Plasma, Takeda's BioLife, and Octapharma, which compensate donors. Collected plasma is utilized for therapies by large pharmaceutical companies, highlighting both the industry's complexity and its reliance on donor participation.