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refactoring involves rewriting a natural genetic sequence for our various purposes often the goal is to transfer processes from one organism to another but in other cases the goal is more subtle in this study Indian co-workers rewrite the t7 phage genome to have well-defined Gene boundaries amendable to bior Brick style cloning methods it was the first introduction to the idea of rewriting a genetic circuit to make it more engineerable through refactoring the t7 f inxy coli and is encoded by a 40 KV genome encoding 55 proteins it is extensively well studied from the perspective of traditional genetics and a great deal is known about the role of each protein many of these proteins are involved in forming the proteinous shell of the Fage While others are involved in DNA replication and packaging steps lces of the cell and a great deal of regulation in previous studies the authors had done computational models to t7 Fage but were unable to make predictions about about the effects of mutat