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To run Smile Design in Medit Link, follow these steps: 1. Access the Case Box (Clinic Account) or Work Box (Lab Account) and select a case with 2D images. 2. Click the icon in the upper right corner of the Case Detail window to open the app, and import the necessary images from the selected case. This process helps define guidelines for smile design and allows for modifications to improve detection results. If the lip line and facial guidelines are accurate, proceed to the design phase. There's also a privacy feature to blur patients' eyes. Ensure the alignment of the two imported images is correct to avoid issues with the design.