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In America, blood is a multibillion-dollar industry, valued at $3.3 billion in 2021. The North American blood market is crucial, with America's blood contributing over 2% of U.S. exports. However, meeting the high demand is challenging, leading to a current one-day supply of blood and sporadic shortages that can have life-or-death implications. Despite its significance as a public health resource, hurdles exist, particularly for certain groups like gay men, who face restrictions on blood donation. A historic FDA study may reverse this ban. Major players in blood collection include Grifols, CSL Plasma, Takeda's BioLife, and Octapharma, where donors are compensated, and plasma is utilized for pharmaceutical therapies.