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I want to keep this ver interactive and I have a bunch of slides but you know I donamp;#39;t need to get through them I just want to make sure that people leave kind of with the you know good understanding of whatamp;#39;s whatamp;#39;s the inherited basis or how to approach a complex disease into thinking about the genetics and Iamp;#39;m gonna focus on the disease that weamp;#39;ve worked on heart attack but the principles are relevant to really every disease that has a genetic in letamp;#39;s say a lifestyle component a complex disease okay so letamp;#39;s start with just thinking through a patient actually because we a lot of our work at least and a lot of the work here at the Broad was inspired by specific problems right human human disease problems and hereamp;#39;s one this is a 42 year old male who presented with dizziness and profuse sweating and which you can see here and this is the actual ambulance sheet for that person stretcher brought into the residence the patie