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the Miss study is a study we started u four years ago um we wanted to investigate whether endovascular treatment um is beneficial in patients with ischemic stroke we got funded by the Dutch Heart Foundation um and we set up a study uh including 500 patients randomizing between standard uh treatment standard treatment for acute stroke U can be with uh intravenous alpl uh So-Cal trombolisis um and the other group uh was the group who received U additional endovascular treatment uh in which we allowed uh well most available treatments right now um so uh one could use uh modern uh catheters like the stren retrievers for instance well um when when we started we didnamp;#39;t know the results of the studies which were published in 2013 in the New England Journal of Medicine um and we we knew that several studies were enrolling patients but um um well we we thought about it and we saw that um well there were studies which were comparing uh directly endovascular treatment with intren therapy