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The brain exhibits high plasticity from birth until around age 25, allowing for significant learning during this period. As we age, although we gain more control over our lives, brain plasticity decreases. Research, including Nobel Prize-winning studies, shows that the neuromodulator acetylcholine is secreted when we focus on specific stimuli. This acts as a spotlight in the brain, enhancing the activity of certain synapses, making them more likely to activate again. For instance, when hearing a beloved song, the acetylcholine secretion creates a deep association, effectively wiring that song into our nervous system, making us feel its impact profoundly.