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etpv and amylofibrosis are quite different among themselves I would say that etnp we resemble each other they come with a high blood count and they have a relatively good quality of life and a good expectation of a survival in ET that will be close to normal TV about the same and only monofibrosis is the one that affects this longevity a lot so the issues here are controlling the disease but then eliminating it and letamp;#39;s take an example of a interferon as a therapy for policy temio better where we have a very good evidence that there is a potential to decrease or even eliminate in about 20 percent of the patients after five years of therapy with interferon malignant clone this is what we call a molecular response and if we can extend that type of experience to other therapists in ET and mouth fibrosis particularly monofibrosis then we would make a difference for outcome of our patients so rather than focusing on immediate needs of controlling the blood cell count symptoms and s