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LSD, also known as acid is a psychedelic drug famous for altering your perception and creating hallucinations. But how does it actually works and what is the effect on your body and more importantly, your brain? Lysergic acid diethylamide was first synthesised in 1938 from the fungus that grew on rye. In 1943, the inventor Albert Hofmann accidentally touched some to his mouth, got high and became the first person in the world to learn about psychedelic properties of LSD. Research on the drug took place in the 50s and 60s, but as recreational use began to spread, psychedelic drugs were made an illegal Schedule I drug in the US and research programs were haulted. While other drugs are dosed in grams, a single dose of LSD is measured in one 100,000th of a gram, which is one 10th the mass of a grain of sand. LSD affects multiple brain receptors such as the dopamine receptors, adrenergic receptors, and glutamate receptors. But most research is on the stimulatory serotonin receptor 5H2TA LS