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hello my name is asean Im a PhD candidate at the Perkins Lab at uottawa and today Im going to explain my research on cell type specific DNA signatures of transcription Factor binding as we know we have multiple transcription factors that combine to multiple regions along the genome and different cell types and the difference in binding may be due to the intrinsic binding behavior in the transcription factor in question or it could be due to other mechanisms such as chromatin accessibility competitive binding and alternative splicing and these mechanisms could result in a DNA signature of differential binding now we use the term DNA signature to Encompass the different mechanisms that could lead to the differential binding preference of the transcription factor in question to study the cell type specific DNA signature of transcription factors we propose a two-step deep learning method called signatures or transcription Factor binding to detect and quantify cell type specificity in a