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hi this is dr max fog university of california davis in sacramento california weamp;#39;ll be finishing off our introductory derm path series covering special stains and patterns of inflammatory skin disease so first in order to stain and properly evaluate tissue the tissue needs to be properly preserved or fixed and the vast majority of our skin specimens are placed in formalin and are then paraffin embedded so-called ffpe formalin-fixed paraffin-embedded tissue so what is this formula and that weamp;#39;re putting all of these little pieces of skin into if you want to answer this question please pause and look at the choices for the dermatopathologist in training the correct answer is a 37 to 40 formaldehyde and if you look at the label on the specimen bottles that youamp;#39;re using it usually says 10 neutral buffered formalin so the formalin is diluted down further to a 10 neutral buffered solution notice also the biohazard warnings on the specimen bottle label and the hazard b