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how does misopristol work misapristol causes cervical ripening dilation cervical softening uterine contractions routes of administration oral route of administration take misapristol tablets with water misapristol takes 30 minutes to have effect buckle route of administration misapristol tablets are placed between the gums and cheeks they must be kept there approximately 30 minutes until they dissolve and then the remaining portions should be swallowed with water sublingual root of administration misopristol tablets are placed under the tongue they must be kept there approximately 30 minutes until they dissolve and then the remaining portions should be swallowed with water vaginal route of administration misopristol tablets should be moistened with a saline solution and then introduced immediately in the vaginal cavity the patient should rest for 60 minutes misapristol is an exogenous prostaglandin it acts on the myometrial cells in the uterus and it binds to prostaglandin rece