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this is patrice wendling speaking with dr bertram pitt at the european society of cardiology doctor you just presented a data on the subgroup analysis of the high risk groups in the emphasis hf trial could you tell us a little bit about those findings weve looked at various pre-specified high-risk subgroups patients over the age or equal to 75 years people with diabetes mellows people with renal disease with a gfr less than 60 people had an injection fraction less than 30 percent and people had a blood pressure less than the median now in the aged group people over 75 clinicians are rightly worried uh these people were all on standard therapy and acer and knob and a beta block of adding something else and you dont want to precipitate hypertension or further renal disease but we look at our data in that subset we have the same efficacy and the same safety so it really is impressive the diabetes subset is particularly interested interesting because theres been work from scotland dr s