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The earliest known pregnancy test dates back to 1350 BC in Ancient Egypt. ing to the Egyptians, all you have to do is urinate on wheat and barley seeds, and wait. If either sprouts, congratulations, youre pregnant! And if wheat sprouts faster, its a girl, but if barley, its a boy. In 1963, a small study reproduced this test and found that it predicted pregnancy with a respectable 70% accuracy, though it couldnt reliably tell the sex of the baby. Scientists hypothesized that the test worked because pregnant womens urine contains more estrogen, which can promote seed growth. Now its easy to take this ancient method for granted because modern pregnancy tests give highly accurate results within minutes. So how do they work? Over-the-counter pregnancy tests are all designed to detect one thing: a hormone called HCG. HCG is produced in the earliest stages of pregnancy and starts a game of telephone that tells the body not to shed the inner lining of the uterus that month. As th