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ESCTV Barcelona at ESC 2022 with Stefan James and Jo Young Han discussing results of the FRAME AMI trial comparing FFR-guided PCI and angiography-guided PCI for treating non-culprit artery lesions in patients with multivessel disease and ACS. Primary endpoint was composite of death, MI, and revascularization. Study included 562 patients with results showing primary endpoint occurred less frequently in FFR-guided group over 3.5 year follow-up.