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If you have heart failure, your heart may have weak or damaged ventricular walls that can't push enough blood out, or stiff and thickened walls that prevent enough blood from filling the heart. Left-sided heart failure means not enough oxygen-rich blood reaches your body, causing tiredness and breathlessness. It also raises blood pressure, forcing fluid into your lungs. Right-sided heart failure results in blood build-up in veins, leading to edema throughout the body.