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The NMDA receptor is one of two main glutamate receptors, along with the AMPA receptor, found in synapses. Both receptors are permeable to sodium and potassium ions, but NMDA receptors are often blocked by magnesium ions at resting membrane voltages. Weak stimulation typically activates AMPA receptors, leading to slight depolarization of the postsynaptic neuron. This selective activation of receptors plays a key role in synaptic transmission within the hippocampus.
