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every brain function from consciousness to motor control depends on communication between brain cells called neurons the vast majority of this communication occurs through specialized point-to-point contacts called synapses which consists of a pre and a postsynaptic compartment in response to stimulation a neuron releases signaling molecules called neurotransmitters from the presynaptic compartment subsequently the neurotransmitter binds to receptors on the postsynaptic compartment of the downstream neuron generating another electrical signal the release of neurotransmitters from the pre synapse is heavily regulated through a complex of proteins at the site of release the active zone however the precise role of many of these proteins has remained unclear researchers recently demonstrated that two of these proteins get one and get to regulate synaptic communication through distinct presynaptic mechanisms get one and get to our members of a family of proteins that were first found to int