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Hypersensitivity refers to abnormal reactions of the immune system against certain antigens. It includes exaggerated reactions to otherwise harmless environmental antigens, commonly known as allergies; and inappropriate reactions against the bodys own antigens, or autoimmune diseases. Reactions can range from a mild rash, to damaged organs, to fatal anaphylactic shock. There are 2 principal groups of factors contributing to hypersensitivity: - Imbalance between effectors and regulators of immune response: in some people, mechanisms that normally moderate the immune system are compromised, causing it to overreact to harmless, non-infectious antigens. - Self-reactivity of immune cells: during their development in the thymus and bone marrow, T-cells and B-cells learn to not react to the bodys own antigens; self-reactive cells are normally eliminated; but in some people, some of these cells escape and may attack their own tissues once activated. Hypersensitivity reactions only occur in p