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The first is the referral and the speedy referral, which I think for the most part works relatively well in younger patients, but I am somewhat concerned, and this is not unique to the UK that elderly and older patients are not necessarily referred with the same frequency as the younger ones, because it is deemed to be futile and the treating physician might say, well, palliative care is fine, not recognizing that actually, we have improved options. Once the patient is at a center that offers trials, I think the UK has been exemplary, as many European countries, in providing one protocol as the national protocol for uniform treatment of patients, and I think the discipline of all the participating centers has been excellent and has generated a huge amount of data, so those procedures are pretty standard. The informed consent is is also routine, that is no longer a question that the patients are informed well together with their family or their GP or whoever they want to consult. They
