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- Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life. [upbeat rock music] Im Andrew Huberman, and Im a professor of neurobiology and ophthalmology at Stanford School of Medicine. Today we are going to be discussing bipolar disorder, often called bipolar depression. Bipolar depression is a condition in which people undergo massive shifts in their energy, their perception, and their mood. However, it is very important to note that these shifts in mood, energy, and perception are all maladaptive. They can often cause tremendous damage to the person suffering from bipolar disorder and tremendous damage to the people in their lives. Today we are going to parse the biology that leads to these shifts in mood, energy, and perception. And we are going to talk about the various treatments that exist. Some of those treatments have been around for a very long time, and indeed one of those treatments, lithium, has an incredible backstory about