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there is one and only one important reason to take berberine supplements but the health industry will try and convince you itamp;#39;s a miracle supplement that improves blood sugar control weight loss and heart health there was even a recent viral video that concluded that berprene supplements shrinks blood vessel plaque and blockages berberine has been used for thousands of years and itamp;#39;s derived from a plant when itamp;#39;s tested in the lab berberine activates an enzyme called ampk which is an important Pathway to help treat type 2 diabetes but in clinical medicine we use a different medication called metformin to activate ampk which is also derived from a plant so why do we use metformin and not berberine well metformin is easily absorbed but the body struggles to absorb berberine and the small amount that is absorbed is quickly broken down by the liver but what about for non-diabetics do we want to use a supplement to activate ampk as explained in a recent video on Met