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you might not have known this but Mirtazapine is actually more sedating at lower doses than it is at higher Doses and this is one of the reasons that the Mantra of start low and go slow might not necessarily be best when youamp;#39;re using this medication so as you can see here Mirtazapine is more sedating at lower doses less than 30 milligrams than it is at higher doses greater than 30 milligrams this is because it is speculated to be more nor adrenergic at higher Doses and thereamp;#39;s a really great article I wanted to show you guys from UCLA and if you take a look here they give a case report of a 90 year old woman who was hospitalized for failure to thrive who complained of insomnia and was given Mirtazapine 7.5 milligrams subsequently the next day she was somnolent and barely arousable workup for delirium was non-revealing Mirtazapine was discontinued and her sedation progressively resolved so just really quickly a review of the mechanism of action of Mirtazapine but basical
