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Nurse Mike introduces the concept of heart failure, explaining that it occurs when the heart fails to pump blood forward, causing fluid to back up into the body. Right-sided heart failure results in peripheral edema, while left-sided heart failure leads to pulmonary edema. Any significant weight gain, such as over three pounds in one day or five pounds in seven days, is concerning and potentially life-threatening. Remember to access free quizzes and study guides on Simple Nursing's website.