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[Music] chromatin function is one of the most active areas of biomedical research it plays major roles in controlling gene expression and is regulated by a complex interplay of chromatin-associated proteins and histone post-translational modifications or ptms defects in chromatin regulation are observed in nearly every type of human disease including cancer mapping of local chromatin features is thus essential to understanding chromatin regulation and its role in disease although much progress has been made further advancements are limited by the power of current technology namely chromatin immunoprecipitation or chip but a new approach could make the problems with chip a thing of the past cut and run short for cleavage under targets and release using nuclease builds on the chromatin immunocleavage or chick approach to provide researchers higher resolution with lower cell input and sequencing requirements than previously possible to appreciate this new tier of performance lets review
