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well thanks for the kind introduction and Id like to give you guys a flavor of some of the things that we were doing it that weve experienced at GSK theyre just sort of a brief overview Ill be talking about anti-drug antibody assays that we are using in the clinic give you an idea the format some interference that we experienced and two particular approaches that we used to try and eliminate it and then do a little review of sa cup points and then some regulatory feedback so anti-drug antibody assays theyre sort of a tiered approach you have a screening assay to try and reduce the number of samples that then go on to your confirmatory assay and those that then confirmed positive thats what gets reported to the regulatory ancient agencies and those are further characterized with a trainer assay to give you an idea of what the the relative responses one of the where the ad a results are never a standalone its all sort of results you always have to look at those in context to eith