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let me speak a little bit about the mechanism of action of trifler Dean to Pierre Asil and I want to emphasize this is not 5 fu and I think youamp;#39;ll see why when I explained about the mechanism of action and compare the two as the name suggests trifler Dean to Paris ill is a combination of two different agents the try flora Dean is a nucleoside metabolic inhibitor however it is rapidly degraded and requires an inhibitor of the enzyme that degrades at thymidine phosphorylase so that it will have more persistence thatamp;#39;s where the Tippie result comes in itamp;#39;s an inhibitor of thymidine phosphorylase when try Floridian is taken up into a cell itamp;#39;s incorporated its DNA in this inhibits DNA synthesis the eventual effect is it inhibits cell cycling in proliferation of malignant cells this contrasts with the mechanism of action of 5-fu 5-fu is an inhibitor of thymio AIDS synthase is you may recall whatamp;#39;s often given with lennick acid which allows more tight