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What Iamp;#39;ll try to do in the next 40 or so minutes is first give you a little bit of background as to how we developed adult stem cell-based organoid technologies. Itamp;#39;s very different and complementary to IPS cell-based organoids, give some applications rapidly and in cancer research, and then Iamp;#39;ll focus on the paper that you see named here. I guess today is assumed to be a little bit of a journal club, so Iamp;#39;ll try to do my best there. What you see here is a crypt villus unit of the small intestine of a mammal. A colon is very similar, it doesnamp;#39;t have villi, It has a flat surface epithelium but most of the rules for the small intestine hold for colon. Cells are produced in crypts. They take about two days while they rapidly proliferate to move up, leave the crypts, differentiate out, live for another two days, maybe 10 different cell types can be recognized now, and four or five days after they are born, they die at the tips of the vilIi and they u