Cut off point in AFP smoothly

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Aug 6th, 2022
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How to Cut off point in AFP

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hi everyone today were going to talk about a really high deal topic its about a cut-off point they like to ask what will happen if we move the cutoff regional here an X point either 2a or 2b but first we have to understand what is this diagram ok so imagine this side is for people who has a positive test and they have the disease so positive test plus disease will be true positive okay in the other side we have healthy people with negative tests so if youre healthy and you have negative tests this will be a true negative and in the middle we have this false negatives here in the side and false positive okay but before we continue we have to remember some things first its this chart its really really well not really ideal you have to memorize it you have to know it really really well okay in this case again this is talking about the disease this is and this is talking about if youre healthy or not so again if you have the disease and test is positive you will be a true positive a

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Normal and Critical Findings Maternal AFP levels in pregnancy start to rise from about the 14th week of gestation up until about 32 weeks of gestation. Between 15 and 20 weeks, AFP levels usually range between 10 ng/ml to 150 ng/ml.
A positive test with a high AFP suggests a birth defect like spina bifida. That's typically a result of 2.5 times or more than the "average" level of AFP you'd expect to see at that point in your pregnancy. A positive test with low AFP could mean a problem like Down syndrome or Edwards syndrome.
Normal and Critical Findings Between 15 and 20 weeks, AFP levels usually range between 10 ng/ml to 150 ng/ml. Adult blood levels greater than 200 ng/ml in patients with liver cirrhosis strongly indicate hepatocellular carcinoma.
In the majority of pregnancies involving a Down's syndrome (DS) fetus, the level of alpha-fetoprotein (AFP) measured in maternal serum and amniotic fluid is reduced to about 70 per cent of the level attained in normal pregnancies.
Here is the normal range: For adults: less than 40 ng/mL. At 15 to 21 weeks' gestation: 10 to 150 ng/mL.
Results are given in nanograms per milliliter (ng/mL). Here is the normal range: For adults: less than 40 ng/mL. At 15 to 21 weeks' gestation: 10 to 150 ng/mL.
Lower than normal AFP levels may mean your baby has a genetic disorder such as Down syndrome, a genetic disorder that causes intellectual disabilities and health problems.
High levels of AFP may be a sign of cancer of the liver, ovaries, or testicles. But having a high AFP level doesn't mean you have cancer or that you will get cancer. Liver injury and liver diseases that aren't cancer can also cause high AFP levels.
A positive test with a high AFP suggests a birth defect like spina bifida. That's typically a result of 2.5 times or more than the "average" level of AFP you'd expect to see at that point in your pregnancy. A positive test with low AFP could mean a problem like Down syndrome or Edwards syndrome.
The singleton pregnancy detection rates are 88% for anencephaly and 79% for open spina bifida (false-positive rate, 3%). Down syndrome risk is based on MoM values of all 5 markers and maternal age at time of delivery....Alpha Fetoprotein (AFP) Quad Screen, Penta Screen, Test Summary. DisorderNormal ScreenDown syndromeRisk <1:270Trisomy 18Risk <1:1005 more rows

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